Anaphylactic and Anaphylactoid Causes of Angioedema

      Anaphylaxis was defined at a conference sponsored by the National Institute of Allergy and Infectious Diseases/Food Allergy and Anaphylaxis Network as “a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy-causing substance” [
      • Sampson H.A.
      • Munoz-Furlong A.
      • Campbell R.L.
      • et al.
      Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
      ]. It has been described as “a serious allergic reaction that is rapid in onset and may cause death” [
      • Sampson H.A.
      • Munoz-Furlong A.
      • Campbell R.L.
      • et al.
      Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
      ]. The Joint Task Force on Practice Parameters, which represents the American Academy of Allergy, Asthma and Immunology; the American College of Allergy, Asthma and Immunology; and the Joint Council of Allergy, Asthma and Immunology, defined anaphylaxis as “a condition caused by an IgE-mediated reaction. Anaphylactoid reactions are defined as those reactions that produce the same clinical picture as anaphylaxis but are not IgE-mediated” [
      • Lieberman P.
      • Kemp S.F.
      • Oppenheimer J.
      • et al.
      The diagnosis and management of anaphylaxis: an updated practice parameter.
      ]. Simons [
      • Simons F.E.R.
      Anaphylaxis, killer allergy: long-term management in the community.
      ] has suggested that anaphylaxis be categorized as immunologic (IgE or Fc ɛ RI mediated), nonimmunologic, or idiopathic. Pseudoallergic is synonymous with anaphylactoid.
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